He was talking about how he must - at a minimum - go on at least one 6-week road trip per year. And his sage advice was:
"...when embarking on a road-trip, when you think you've gone far enough, go just a little bit farther." This is where the true rewards come from.
I felt as though he was literally speaking TO ME. This is a dream of mine. To travel all of North America on an unscripted journey in an RV or similar traveling device. No schedule. No plan.
As a trader with a satellite internet connection, I could work from anywhere. So, it wouldn't even technically be a "vacation", but it would be in so many ways.
I need to make enough money soon so my wife no longer has to work and can therefore travel with me. There's no way she'd let me go alone for 6+ weeks..... though a man can dream :)
Here's a related article: http://www.architecturaldigest.com/homes/homes/2008/11/mcconaughey_article